Help for Pre-Implantation Pregnancy Failure

Bitter-Sweet with No Guarantees

When a couple wants to have a baby and they are struggling with infertility, it seems no price is too high to pay in order to achieve their desire. Most turn to in vitro fertilization with the hope of ending their barrenness and have the child of their dreams. The problem with IVF is that it is a costly procedure that carries no guarantee of a baby. Many women endure several rounds of IVF with no success - the emotional and physical impact is often devastating.

Intralipid, An Older Treatment with a New Focus

New methods come on the scene regularly to address unsuccessful IVF therapy. One such method is the use of Intralipid, a soy bean based oil that has been used for several years as a way to nourish patients in hospitals who are unable to eat normally due to serious injury or trauma. Intralipid has been around for several decades however, it is only recently that it has been used to help women undergoing IVF to conceive. It is used expressly in connection with pre-implantation pregnancy loss, the point in time between fertilization of the egg and implantation in the uterine wall.

Why an Embryo Doesn\'t Implant

There are only two reasons an embryo may not successfully implant - something is wrong with the embryo or something is wrong with the uterine environment, either at a physical or molecular level.

The most common issue related to the embryo is an abnormality with the number of chromosomes and 95% of chromosomally abnormal embryos are abnormal as a result of something problematic with the egg. The egg is responsible for accepting the DNA from the sperm then mixing the genes to create a new individual. The age of the egg determines the normalcy of the embryo. Eggs from women under the age of 30 are chromosomally normal in about 50% of cases. When the woman is at age 45, the percentage drops to 5% normalcy. An additional consideration is that each embryo that is chromosomally normal stands a 30% chance of making it to birth.

When the Uterus is the Problem

When it comes to uterine environment, the problems are structural, hormonal or immunological.

· Structural problems include endometrial polyps, submucus fibroids or intracavity adhesions - all of which act like an IUD and interfere with implantation.

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